Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan. Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua, Taiwan. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua, Taiwan; Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan; Graduate Institute of Integrative Medicine, China Medical University, Taichung, Taiwan.